Thyroid Hormone Action: Astrocyte–Neuron Communication
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چکیده
منابع مشابه
Thyroid Hormone Action: Astrocyte–Neuron Communication
Thyroid hormone (TH) action is exerted mainly through regulation of gene expression by binding of T3 to the nuclear receptors. T4 plays an important role as a source of intracellular T3 in the central nervous system via the action of the type 2 deiodinase (D2), expressed in the astrocytes. A model of T3 availability to neural cells has been proposed and validated. The model contemplates that br...
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SUMMARY The foliowing cardiac effects may be attributed to thyroxin: 1-Thyroxin augments all anaerobic processes in the body includ::ng the heart, and decreases the glycogen content of the heart ( 1, 2, 5, 27). The resistance of the heart to anoxia is increased in hyperthyroidism ( 25). 2- Thyroxin influences the cardiac weight and prevents cardiac atrophy (3, 8, 10, 11, 19, 20, 21, 30...
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Thyroid hormone (triiodothyronine [T3]) regulates gene expression by binding to high-affinity nuclear receptors. Thyroid hormone receptors (TRs) recognize specific response element sequences in the promoters of T3-target genes and activate or repress transcription in response to hormone. In this paper, we review the TR proteins and thyroid hormone response elements (TREs) to which they bind, th...
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• Rohit Sinha, M.D. Research Fellow Laboratory of Hormonal Regulation Cardiovascular and Metabolic Disease Program Duke-NUS Graduate Medical School 8 College Road, Level 8 Singapore 169857 • Paul M. Yen, M.D. Associate Professor Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disease Program Duke-NUS Graduate Medical School, 8 College Road, Level 8, Singapore 169857 Molecular Re...
متن کاملMechanisms of thyroid hormone action.
Our understanding of thyroid hormone action has been substantially altered by recent clinical observations of thyroid signaling defects in syndromes of hormone resistance and in a broad range of conditions, including profound mental retardation, obesity, metabolic disorders, and a number of cancers. The mechanism of thyroid hormone action has been informed by these clinical observations as well...
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ژورنال
عنوان ژورنال: Frontiers in Endocrinology
سال: 2014
ISSN: 1664-2392
DOI: 10.3389/fendo.2014.00082